Journal: BioMed Research International

Article Title: Identification of Gastric Cancer-Related Circular RNA through Microarray Analysis and Bioinformatics Analysis

doi: 10.1155/2018/2381680

Figure Lengend Snippet: Differentially expressed miRNAs in tumor tissues and adjacent normal tissues from gastric cancer patients. The box plot shows the variations in miRNA expression. Each group consists of twenty samples.

Article Snippet: The original miRNA expression profile of GSE23739 used in the present study was downloaded from the National Center of Biotechnology Information Gene Expression Omnibus (GEO).

Techniques: Expressing

Journal: PLoS Computational Biology

Article Title: Statistical Use of Argonaute Expression and RISC Assembly in microRNA Target Identification

doi: 10.1371/journal.pcbi.1000516

Figure Lengend Snippet: Marginal correlations of m- and miRNA expression levels are typically and inappropriately positive in all datasets under analysis. Further, in the Madison and Broad datasets the amount of variation in targeted mRNA expression captured by that of targeting miRNA is extremely low. In the combined dataset, high R 2 values are indicative only of the amount of variation in mRNA expression due to data origin.

Article Snippet: The second data source was derived from that produced from a study of miRNA expression patterns over a wide variety of tumor and normal tissue types conducted by the Broad Institute .

Techniques: Expressing

Journal: PLoS Computational Biology

Article Title: Statistical Use of Argonaute Expression and RISC Assembly in microRNA Target Identification

doi: 10.1371/journal.pcbi.1000516

Figure Lengend Snippet: Improvements in the percentages of variation in targeted mRNA expression are observed through use of the adjusted R 2 statistic. Partial correlations of proxies to targeting Ago 2 RISCs and targeted mRNAs are lower than those of m/miRNA expressions. Paired Wilcoxon tests of the hypothesis H 0 : μ 0 −μ 1 = 0 vs. H A : μ 0 −μ 1 ≠0 were rejected for the Madison ( p = 0.0135), Broad ( p = 0.0186) and combined ( p <0.0001) datasets, where μ 0 and μ 1 refer to mean correlations of marginal m/miRNA expression and mean partial correlations respectively.

Article Snippet: The second data source was derived from that produced from a study of miRNA expression patterns over a wide variety of tumor and normal tissue types conducted by the Broad Institute .

Techniques: Expressing

Journal: PLoS Computational Biology

Article Title: Statistical Use of Argonaute Expression and RISC Assembly in microRNA Target Identification

doi: 10.1371/journal.pcbi.1000516

Figure Lengend Snippet: Hash marks denote the 95% confidence level of identification numbers under the no-targeting null for the miRNA and validation technique under consideration. Overall, 7.83% of computational predicted targets were verified using marginal expression level comparisons, and 4 miRNAs showed substantially larger numbers of verifications than what would be typically expected. After compensating for biological and idiosyncratic effects, 25.68% of these targets were verified, and 9 miRNAs showed large numbers of identifications.

Article Snippet: The second data source was derived from that produced from a study of miRNA expression patterns over a wide variety of tumor and normal tissue types conducted by the Broad Institute .

Techniques: Biomarker Discovery, Expressing

Journal: PLoS ONE

Article Title: Diet-Induced Obesity Modulates Epigenetic Responses to Ionizing Radiation in Mice

doi: 10.1371/journal.pone.0106277

Figure Lengend Snippet: miRNA regulations in the livers of non-irradiated and irradiated C57BL/6J mice fed a normal or HF diet, determined using Significance Analysis of Microarrays (SAM).

Article Snippet: The profiling of miRNA expression levels was performed using the miRCURY LNA miRNA profiling service (Filgen).

Techniques: Irradiation